This species is also bred and sold as aquatic pets, often under name African dwarf frog that also includes other Hymenochirus species. As pets, African dwarf frogs can live peacefully among other fish in an aquarium. Their tank mates should be neither large enough to pose a predatory threat to the frogs, nor small enough to become food for the frogs themselves.
They are not an especially demanding species, and can be kept in most standard aquarium setups. Seeing as how they must breathe air to survive and can escape from the tank, aquariums that are not too tall and are well-covered are a must. They can be fed a diet of suitably-sized food items designed for use with aquarium fish, including live, frozen and freeze-dried bloodworms, tubifex worms, and brine shrimp. These frogs are not picky but overfeeding will quickly lead to obesity. They will also eat any form of prepared food that sinks to the bottom.